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Assessment of bacterial translocation in obstructive jaundice using Tc-99m Escherichia coli BABT
Diniz,Simone Odília Fernandes; Barbosa,Alfredo José Afonso; Araújo,Ivana Durval; Nelson,David Lee; Machado,Leonardo Augusto da Silva; Bernardo Filho,Mário; Cardoso,Valbert Nascimento.
In obstructive jaundice, the passage of bacteria and endotoxins through the intestine wall to reach the systemic circulation is associated with septicemia, renal failure and pulmonary dysfunction. The aim of this work was to investigate bacterial translocation utilizing 99mTc-E.coli in an experimental model of obstructive jaundice. The levels of bilirubin in rats that were subjected to ligature of the bile duct were significantly increased when compared to control animals (p < 0.001). The biodistribution results did not show any translocation of 99mTc-E.coli to the mesenteric lymphatic nodules, liver, spleen or lungs of the rats that suffered ligature of the bile duct (p > 0.05). The evaluation of the intestinal permeability using "per os"...
Tipo: Info:eu-repo/semantics/article Palavras-chave: Bacterial translocation; Technetium-99m E coli; Obstructive jaundice.
Ano: 2005 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1516-89132005000700006
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Evaluation of the phagocitary capacity of the mononuclear system in an experimental model of obstructive jaundice employing Tc- 99m Escherichia coli BABT
Diniz,Simone Odília Fernandes; Barbosa,Alfredo José Afonso; Araújo,Ivana Durval; Nelson,David Lee; Machado,Leonardo Augusto da Silva; Cardoso,Valbert Nascimento.
Infections and endotoxemia continue to be the principal causes of morbidity and mortality of patients with obstructions of the bile duct. The objective of the present work was the investigation of the phagocitary capacity of the mononuclear system in an experimental model of obstructive jaundice utilizing Tc-99m E.coli. The levels of aspartate aminotransferase (AST), alanine aminotransferase (ALT) and alkaline phosphatase (ALP) were significantly higher in jaundiced rats than in the control animals (p < 0.001). The liver of the jaundiced animals presented a significant reduction in Tc-99m E.coli uptake when compared to the controls (p < 0.001). The data also showed that there was a significant increase in the uptake of Tc-99m E.coli by the lungs of...
Tipo: Info:eu-repo/semantics/article Palavras-chave: Mononuclear phagocyte system; Technetium-99m E. coli; Obstructive jaundice.
Ano: 2005 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1516-89132005000700005
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